高峰譲吉博士研究会

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高峰&上中両博士のアドレナリン結晶化の経緯についてまとめた英文論文が
医学書に採用


Accepted Dr. Jokichi Takamine’s English paper on the history of adrenaline crystallization for publication in a medical journal.

脳神経外科の専門医であり脳科学研究者である山嶋哲盛氏の高峰譲吉博士のアドレナリン結晶化の経緯に関する英文論文が医学書に採用されました。 山嶋氏は当研究会の会員でもあり、海外の方へ高峰博士の情報発信を行う一環として論文のご提供を頂きましたので掲載いたします。なお、専門的な内容を含む英文論文ですが、邦訳等は御座いません。予めご了承ください。

An English paper by Dr. Tetsumori Yamashima, a neurosurgeon and neuroscience researcher, has been accepted for publication in a medical journal, Highlights on Medicine and Medical Research Vol. 10. Dr. Yamashima is also a member of our research foundation and provided us with his paper as part of our efforts to disseminate information about Dr. Takamine to people overseas.




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Adrenaline Hunters: Past, Present and Future at 1900
Tetsumori Yamashima


ABSTRACT
Adrenal gland was first described by the Italian anatomist Eustachio in 1564, but its physiologic role remained unknown for three centuries. Even after the report of Addison’s disease in 1855, nobody knew its function. Oliver and Schäfer first discovered the blood pressure-raising property of adrenal extracts in 1894. Accordingly, in the late 1890’s, highly motivated scientists had directed their attention to isolate active principle for the therapeutic utilization, but all failed. For instance, Abel’s preparation ‘epinephrine’ was an inactive benzoylated derivative. In August 5, 1900 the Japanese industrial chemist Takamine and his young associate Uenaka settled in New York, succeeded to crystallize the adrenal extract by a procedure different from any yet employed. The active principle was isolated in the vacuum pan, crystallized with ammonia, and confirmed by the Vulpian reaction.
‘Uenaka’s Experimental Memorandum’ describes that the novel crystal was coined ‘adrenalin’ (no “e”) on November 7, 1900. Simultaneously, Takamine applied the US patent which was approved on June 2, 1903, and Parke, Davis & Company trademarked the name ‘Adrenalin’ to market worldwide. As a hemostatic during surgery and for treating heart failure, adrenaline has saved numerous lives. There are historical, etymological and practical justifications for using the term ‘adrenaline’.

Keywords: Jokichi Takamine Keizo Uenaka Parke, Davis & Co. Adrenaline Epinephrin Vulpian reaction Adrenal medulla Adrenalin Memorandum

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(文責:事務局、記事作成:令和3年5月31日)